The Regan Intrusive Suite of about 100 plutons of tonalite, granodiorite, and quartz diorite intruded the Yellowknife Supergroup and migmatite terrain in the northwest Slave Structural Province 2.59 Ga ago. Rare-earth-element (REE), trace-element, and major-element analyses from 39 representative whole rocks from the suite suggest it was derived by batch melting of the crust, producing a parental magma of tonalitic or granodioritic composition. By analysing REE from different parts of a zoned pluton, it was concluded that REE distribution was controlled by early separation of quartz diorite from the parent magma by flow differentiation and that the bulk of the REE were contained in early, cumulate, accessory apatite and monazite. The residual magma was further fractionated in pipelike magma chambers during ascent into more leucocratic rocks. Chondrite-normalized REE patterns of single-lithology plutons are similar to lithologies in zoned plutons, and it is proposed they initially segregated during ascent. It was found that granites, which were formerly grouped with the suite, formed in three ways, only one of which is related to the Regan Intrusive Suite.Study of 2.67 Ga old synvolcanic tonalite pluton revealed a strong covariance of light REE with those of the bimodal, calc-alkaline Hackett River Group of volcanic rocks. The data imply a common crustal source, but mass balance requires larger volumes of felsic volcanic rocks than are presently preserved, suggesting that much of the erupted felsic pyroclastic rocks were eroded. Partial melts from synvolcanic tonalite during subsequent regional metamorphism differentially depleted host rocks in REE and concentrated Eu and heavy rare-earth elements (HREE) in trondhjemite pegmatites.