The Mesozoic Tyaughton–Methow Basin straddles the Fraser–Yalakom–Pasayten – Straight Creek (FYPSC) strike-slip fault zone between six tectono-stratigraphic terranes in southwestern British Columbia. Data from Hauterivian–Cenomanian basin fill provide constraints for reconstruction of fault displacement and paleogeography.The Early Cretaceous eastern margin of the basin was a region of uplifted Jurassic plutons and active intermediate volcanism. Detritus shed southwestward from that margin was deposited as the marine Jackass Mountain Group. Albian inner to mid-fan facies of the Jackass Mountain Group can be correlated across the Yalakom Fault, suggesting 150 ± 25 km of post- Albian dextral offset. Deposits of the Jackass Mountain Group overlap the major strike- slip zone (FYPSC). If that zone represents the eastern boundary of the tectono-stratigraphic terrane, Wrangellia, then accretion of Wrangellia to terranes to the east occurred before late Early Cretaceous time.The western margin of the basin first became prominent with Cenomanian uplift of the Coast Mountain suprastructure. Uplift is recorded by dispersal patterns of the volcaniclastic Kingsvale Group southwest of the Yalakom Fault.Reversing 110 km of Late Cretaceous – early Tertiary dextral motion on the Fraser – Straight Creek Fault followed by 150 km of Cenomanian – Turonian motion on the Yalakom – Ross Lake Fault restores the basin to a reasonable depositional configuration.