Trilobites of the Callavia Zone s.1. occurring together with phosphatic fossils in the Little Hollow Formation are the first known Early Cambrian faunas from mainland Nova Scotia. The tectono-stratigraphic affinity of the northern Antigonish Highlands with less intensely deformed portions of the Avalonian Platform is indicated by: (1) the Avalonian character of the trilobites and Early Ordovician brachiopods, (2) the nature of the lithologic sequence of the Iron Brook Group, and (3) local evidence for a Hadrynian orogeny.Rhombocorniculum cancellatum (Cobbold) is here informally designated a "pseudoconodont" based on its unique histology and is regarded as a conodontophorid-like organism. Eccentrotheca kanesia n. gen., n. sp. is a multiplated organism with apparent affinities to groups regarded as mitrosagophorans. Sunnaginia imbricata Missarzhevsky and possibly Turcutheca are demonstrated to occur in strata younger than Tommotian (lowest Lower Cambrian).