The North American continent has a rich record of the tectonic environments and processes that occur throughout much of Earth history. This Memoir focuses on seven “turning points” that had specific and lasting impacts on the evolution of Laurentia: (1) The Neoarchean, characterized by cratonization; (2) the Paleoproterozoic and the initial assembly of Laurentia; (3) the Mesoproterozoic southern margin of Laurentia; (4) the Midcontinent rift and the Grenville orogeny; (5) the Neoproterozoic breakup of Rodinia; (6) the mid-Paleozoic phases of the Appalachian-Caledonian orogen; and (7) the Jurassic–Paleogene assembly of the North American Cordillera. The chapters in this Memoir provide syntheses of current understanding of the geologic evolution of Laurentia and North America, as well as new hypotheses for testing.