Earthquake damage is often increased due to local ground-motion amplification caused by soft soils, thick basin sediments, topographic effects, and liquefaction. A critical factor contributing to the assessment of seismic hazard is detailed information on local site response. In order to address and quantify the site response at seismograph stations in the eastern United States, we investigate the regional spatial variation of horizontal:vertical spectral ratios (HVSR) using ambient noise recorded at permanent regional and national network stations as well as temporary seismic stations deployed in order to record aftershocks of the 2011 Mineral, Virginia, earthquake. We compare the HVSR peak...