In the easternmost Himalaya and southeastern Tibet, the Namche Barwa–Gyala Peri massif and adjacent Lhasa block host some of the Earth’s most active geologic processes and extreme topography. Synthesis of U-Th/He and Ar-Ar thermochronology, anatectic history, seismicity, and structural geology shows the important role that surface processes have played in this region in both local and orogen-scale crustal dynamics. Basement rocks of the massif underwent an episode of metamorphism, partial melting, and focused deformation that began ca. 10 Ma and likely remains active due to thermally mediated feedbacks between these processes and erosion. Strong differential rock uplift at Namche Barwa...