Stratigraphic and geomorphic analyses reveal that the regional drainage basin of the modern Amargosa River formed via multistage linkage of formerly isolated basins in a diachronous series of integration events between late Miocene and latest Pleistocene–Holocene time. The 275-km-long Amargosa River system drains generally southward across a large (15,540 km²) watershed in southwestern Nevada and eastern California to its terminus in central Death Valley. This drainage basin is divided into four major subbasins along the main channel and several minor subbasins on tributaries; these subbasins contain features, including central valley lowlands surrounded by highlands that form external divides...