The Caledonian orogen of North-East Greenland hosts numerous mineral occurrences related to (1) pre-Caledonian crystalline complexes (Pb-Zn skarn type); (2) Neoproterozoic basins (strata-bound copper); (3) Caledonian granites (vein-type gold, silver, tungsten, arsenic, and antimony); and (4) late Caledonian extensional structures (vein base metal ± silver). Sr, Pb, and Sm-Nd isotope analyses of scheelite (CaWO₄) indicate a heterogeneous, probably local, source for tungsten, and Sr isotopic data support a genetic link to Caledonian magmatic activity. Pb isotopes indicate mixing of Pb derived from late waning-stage fluids from the granites and from interaction with wall rocks. Sm-Nd isotopic data for...