The Cambrian Nongpoh granitoids, intrusive into the Precambrian gneissic complex and metasediments of the Shillong Group, represent a major phase of granitic magmatism in the Shillong Plateau. The Nongpoh granitoids comprise diorite, granodiorite, porphyritic and grey granites. Porphyritic granite is the dominant lithology exposed in the Nongpoh granitoids, and contains three types of enclaves, viz. xenoliths of gneissic rocks, dark grey porphyry and biotite-rich microgranular enclaves. The mafic magmatic enclaves (MMEs) of various dimensions and shapes, including rounded, ellipsoidal, rectangular, angular to subangular, and stretched bodies, were produced by evolving nature and contrasting kinematics of interacting felsic and mafic magmas. The biotite-rich enclaves are due to the injection of syn-magmatic mafic dykes in felsic magma. The various textural assemblages and sub-linear variations between silica and major oxides, chemical mixing and element diffusion suggest that multistage magma hybridization was the key process during the evolution of the Nongpoh granitoids. The 501 Ma age obtained by chemical (U–Th–Pb) dating of monazite in MME ascertained the age of the magma hybridization event in the Nongpoh granitoids, which is equivalent to the igneous activity at 500 Ma during the amalgamation of Eastern Gondwana.