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Book Chapter

Towards a general model for predicting the toxicity and pathogenicity of mineral fibres

By
Alessandro F. Gualtieri
Alessandro F. Gualtieri
Universita di Modena e Reggio Emilia, Dipartimento di Scienze Chimiche e Geologiche, Via Campi 103, I-41125, Modena, Italy
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Brooke T. Mossman
Brooke T. Mossman
University of Vermont College of Medicine, Department of Pathology, 89 Beaumont Avenue, Courtyard S265 Burlington, Vermont 05405, USA
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Victor L. Roggli
Victor L. Roggli
Duke University School of Medicine DUMC 3712 Durham, North Carolina 27710, USA
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Published:
January 01, 2017

Abstract

This chapter provides a comprehensive description of the physical, chemical, biological and mineralogical parameters that play a role in determining the toxicity and pathogenicity of mineral fibres. The first steps towards a general toxicity/pathogenicity model of mineral fibres are described here. Eventually the model can be generalized and may be applied to biodurable man-made mineral fibres and other natural and synthetic fibres in addition to silicates. Because of the complexity of the topic, a truly multidisciplinary approach is essential. A concept that will be stressed in the final notes of the chapter is that a full understanding of the toxicity/pathogenicity of mineral fibres aimed at finding effective solutions for the prevention and treatment of asbestos-related diseases can only be the outcome if an holistic approach is applied which takes advantage of synergistic research activity and communication between biochemists, mineralogists/crystallographers, pathologists, physicians, physicists and toxicologists, all sharing their distinct but interrelated perspectives. This is a great challenge for all such scientific individuals to work together to resolve and develop predictive models that incorporate their research findings and conclusions.

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Contents

European Mineralogical Union Notes in Mineralogy

Mineral Fibres: Crystal Chemistry, Chemical-Physical Properties, Biological Interaction and Toxicity

A. F. Gualtieri
A. F. Gualtieri
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Mineralogical Society of Great Britain and Ireland
Volume
18
ISBN electronic:
9780903056663
Publication date:
January 01, 2017

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