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Book Chapter

Biological activities of asbestos and other mineral fibres

By
Michele Carbone
Michele Carbone
Thoracic Oncology Program, University of Hawaii Cancer Center, Honolulu, Hawaii USA
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Haining Yang
Haining Yang
Thoracic Oncology Program, University of Hawaii Cancer Center, Honolulu, Hawaii USA
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Published:
January 01, 2017

Abstract

The mechanisms of asbestos carcinogenesis are related largely to the chronic inflammatory response to these fibres when they are lodged in tissues. Mesothelial cells are much more susceptible than other cell types to asbestos and thus individuals exposed to asbestos characteristically develop malignant mesothelioma (MM). The chronic inflammatory response is driven by the release of high mobility group box 1 protein (HMGB1) in the extracellular space by mesothelial cells and by inflammatory cells undergoing programmed cell necrosis caused by asbestos. Genetics influences the individual response to asbestos, and thus individual susceptibility to asbestos carcinogenesis varies. HMGB1 represents a promising biomarker of asbestos exposure to MM and strategies aimed at interfering with HMGB1 and chronic inflammation may help prevent/delay the onset of MM in individuals exposed to asbestos or other carcinogenic fibres. Individuals carrying germline BAP1 mutations can develop any type of cancer, including MM, regardless of asbestos exposure. However, animal experiments suggest that these individuals are also more susceptible to asbestos carcinogenesis, even at low exposure levels, compared to the population at large.

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Contents

European Mineralogical Union Notes in Mineralogy

Mineral Fibres: Crystal Chemistry, Chemical-Physical Properties, Biological Interaction and Toxicity

A. F. Gualtieri
A. F. Gualtieri
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Mineralogical Society of Great Britain and Ireland
Volume
18
ISBN electronic:
9780903056663
Publication date:
January 01, 2017

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