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Book Chapter

In vitro biological activity and mechanisms of lung and pleural cancers induced by mineral fibres

By
Brooke T. Mossman
Brooke T. Mossman
Department of Pathology, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, Vermont 05405, USA
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Armanda Pugnaloni
Armanda Pugnaloni
Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Via Tronto 10/A, Ancona 60020, Italy
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Published:
January 01, 2017

Abstract

The mechanisms of disease of the six naturally occurring asbestos fibres have been studied for decades although critical questions still remain. With the advent of cell and molecular biology, in vitro models have been developed that enable use of sophisticated analytical tools and important collaborations between biologists, geologists and experts in the chemical/physical characterization of not only asbestos, but other minerals in the environment that may have disease potential. This chapter stresses the fact that a number of cellular organelles participate in mineral fibre toxicity and describes the primary properties of pathogenic mineral fibres. In addition, it summarizes new directions in testing of suspect carcinogenic fibres in Italy.

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Contents

European Mineralogical Union Notes in Mineralogy

Mineral Fibres: Crystal Chemistry, Chemical-Physical Properties, Biological Interaction and Toxicity

A. F. Gualtieri
A. F. Gualtieri
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Mineralogical Society of Great Britain and Ireland
Volume
18
ISBN electronic:
9780903056663
Publication date:
January 01, 2017

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