In vitro biological activity and mechanisms of lung and pleural cancers induced by mineral fibres
Brooke T. Mossman, Armanda Pugnaloni, 2017. "In vitro biological activity and mechanisms of lung and pleural cancers induced by mineral fibres", Mineral Fibres: Crystal Chemistry, Chemical-Physical Properties, Biological Interaction and Toxicity, A. F. Gualtieri
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The mechanisms of disease of the six naturally occurring asbestos fibres have been studied for decades although critical questions still remain. With the advent of cell and molecular biology, in vitro models have been developed that enable use of sophisticated analytical tools and important collaborations between biologists, geologists and experts in the chemical/physical characterization of not only asbestos, but other minerals in the environment that may have disease potential. This chapter stresses the fact that a number of cellular organelles participate in mineral fibre toxicity and describes the primary properties of pathogenic mineral fibres. In addition, it summarizes new directions in testing of suspect carcinogenic fibres in Italy.
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Mineral Fibres: Crystal Chemistry, Chemical-Physical Properties, Biological Interaction and Toxicity
The state of the art in the field of mineral fibres is illustrated and discussed here, with a multidisciplinary approach taking into account all the different scientific strands (biology, chemistry, epidemiology, mineralogy, physics, toxicology etc.). The different views have been considered in an attempt to assemble the pieces of the jigsaw and to present the reader with an up-to-date and complete picture.