Intrusion-related hydrothermal systems represent a large variety of geologic environments that in some cases form large metallic mineral deposits. The deposits examined in this trip represent the spectrum from systems dominated by magmatic fluid (Birch Creek, California and Yerington, Nevada) to those systems in which intrusions serve as heat engines to drive convectively circulating brines derived from sedimentary rocks (Hum-boldt, Nevada). In these examples, nonmagmatic fluids are largely excluded from more deeply emplaced intrusions in a compressive environment, and the hydrothermal composition and ores (e.g., granite W-F, Cu porphyry and skarn) are dictated by the composition of the magma and its mechanism of crystallization and aqueous fluid generation. Magmatic fluids are less important in the shallow crustal ore environment, but apparently contribute to acidic alteration zones located vertically above source intrusions. Using Humboldt as an example, we propose that the Fe oxide Cu-Au ores in the shallow environment require an abundant source of sedimentary brines (typical of evaporitic environments), high fracture permeability (promoted by an exten-sional setting) to allow aqueous fluid flow and dike emplacement, and shallowly emplaced intrusions to serve as heat sources.