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Proponents of syngenetic theory base their interpretation largely on widespread uniform mineralization within a restricted stratigraphic interval and a consistent relationship of mineralization to sedimentary features. Proponents of epigenetic theory base their interpretation on mineralization of post-depositional structures, changes in extent and grade of ore, open space filling, district-wide lack of close control by sedimentary features, and relation of ore to tectonic structures. These and other criteria are evaluated in an attempt to define diagnostic criteria.

On the basis of the criteria defined the major lead-zinc deposits of Mid-continent United States must be considered as epigenetic.

Features of the Southeast Missouri lead district are listed. The deposits are epigenetic. The metals are believed to have been derived from nearby sedimentary basins and carried out of basins onto shelf areas in a concentrated brine. Movement of solutions was controlled by basement topography and deposition of metals occurred when solutions entered the Bonneterre formation on the flanks of and over buried knobs.

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