This Special Publication arises from the UNESCO-sponsored IGCP 586-Y project ‘The tectonics and geomorphology of the Andes (32°–34°S): interplay between short-term and long-term processes’. It includes state-of-the-art reviews and original articles from a multidisciplinary perspective that investigate the complex interactions of tectonics and surface processes in the subduction-related orogen of the Andes of central Chile and Argentina (c. 27°–39°S). It aims to improve our understanding of tectonic and landscape evolution of the Andean range at different time scales, as well as the mutual relationship between internal and external mechanisms in Cenozoic deformation, mountain building, topographic evolution, basin development and mega-landslides occurrence across the flat slab to normal subduction segments. The geodynamic processes of the Andes of central Chile and Argentina are analysed from a number of subdisciplines of the Earth sciences, including tectonics, petrology, geophysics, geochemistry, structural geology, geomorphology, engineering geology, stratigraphy and sedimentology.