Both active and passive flexible protection methods are effective against rockfalls, but they can result in a secondary hazard due to cumulate rocks inside the structure. To solve this problem, guided flexible protection systems are receiving increased attention in the engineering community. In this study, a full-scale test of a guided flexible protection system was carried out, where the bottom of the mesh was anchored under a blasting load, which can be considered as an extreme loading event related to rockfall hazards. The fluid-solid coupling method was employed in a finite element model to simulate the entire process from the blast to the accumulation of rocks at the bottom of the slope. Based on the experimental and numerical results, a two-stage process was revealed, the internal force and the dissipated energy of each component were compared and analyzed, and the load-transferring path within the system was obtained. The internal forces of the support ropes reached their maximum values in the intercept stage. The posts experienced two peak values, the first of which, in the guide stage, was twice that in the intercept stage. The brake rings were the main energy-dissipating components, and the energy dissipation in the intercept stage was much greater than that in the guide stage. Furthermore, the interaction in terms of collision and friction between the rocks, the slope, and the system was not insignificant, particularly in the guide stage, which can account for more than 40 percent of the consumed energy of the rockfall.