We used previously obtained marine geophysical and geotechnical data for the proposed Galsi pipeline route from Algeria to Sardinia to analyze the buried salt distribution, rates of fault displacements, and frequency and lateral extent of submarine slope failures. Crossing the convergent African/Nubian–European plate boundary, the southern section of the pipeline route traverses continental shelves and slopes of Algeria and Sardinia as well as the Algerian abyssal plain of the western Mediterranean. Deeply buried Messinian-aged salt is present throughout this area. Being less dense and more buoyant than the overburden sediment, the salt tends to flow upward to form diapiric structures that, in turn, result in the formation of faults and landslides in the overlying sediment. Measured offsets from seismic profiles of different resolutions were compared with predicted sediment age at depth of each offset, yielding an average rate of fault displacement of 1.5 cm/kiloyear (ky). The highest rates of displacement are along the Cagliari slope near Sardinia (2.5-2.7 cm/ky) and near the convergent plate boundary (2.3 cm/ky). Utilizing the same geophysical data, the frequency and lateral extent of submarine slope failures in the study area can also be linked to the distribution of salt and the influence of salt tectonics. Turbidity currents and hyperpycnal flows are present within the Algerian basin, whereas local debris flows, landslide runouts, and channelized debris flows are present along the Sardinian slope. The low sedimentation rates, determined in this study, suggest that the most recent slope failures related to salt tectonics occurred more than 12,000 years ago.