This study focuses on the sedimentary fill of basin 4, the termination of the Brazos-Trinity minibasin slope system in the northwestern Gulf of Mexico. Results from multistratigraphic analyses of 15 giant piston cores provided (1) important information regarding the nature (hemipelagic versus gravity-induced mud and sand deposits) and the timing of the sedimentary fill; (2) some key chronostratigraphic constraints for the evolution of this system; and (3) strong links between well-known cycles of sea level change to clearly imaged deposits in the fill of basin 4. Gravity-flow–induced sedimentation in basin 4 occurred and increased in importance during the stepwise sea level regression that developed between 115 and 15 ka and clearly ceased just prior to the meltwater spike in the Gulf of Mexico dated at about 14 ka. The onset of gravity-induced deposition in basin 4 is dated at marine isotope stage (MIS) 5d (∼115 ka). This finding implies that sandy turbidity currents reached this distal setting as a consequence of a higher frequency sea level fall within a time of general high sea level (MIS 5). An interval of hemipelagic sedimentation lasting from 90 to 45 ka illustrates cessation of gravity-induced deposits in basin 4. Turbidite sandy deposits resumed in mid-MIS 3 and increased toward MIS 2 (approximately from 30 to 15 ka). The largest proportion of reservoir-grade sandy sediment was deposited during the maximum sea level lowstand of the last glacial maximum, consistent with the prevailing view of sequence-stratigraphic models for deep-water deposition.